Reduced Oxygen Levels Could Double Neural Stem Cells? Chance of Survival
Reduced Oxygen Levels Could Double Neural Stem Cells’ Chance of Survival Durham, NC (PRWEB) May 15, 2013 Decreasing the amount of oxygen traditionally used when culturing stem cells for use in neurological therapies could drastically affect their survival rate. In fact, it could double it, according to a new study released today in STEM CELLS Translational Medicine. “Cells are usually cultured in the lab in a 20 percent oxygen environment, a level far removed from the in vivo situation. This is particularly true in the central nervous system, where oxygen tensions — that is, the concentration of oxygen at a specific pressure — are normally around 3 percent,” said Sybil Stacpoole, M.D., Ph.D., lead author on the paper by a team of researchers from the Universities of Cambridge and Edinburgh. “Cell transplantation strategies therefore typically introduce a stress challenge at the time of transplantation as the cells are switched from 20 percent to 3 percent oxygen, which is th Read more text